CenTrate™ BMA Device
Bone Marrow Aspirate Concentration
CenTrate is a proprietary bone marrow aspirate concentration device whose output produces a natural suspension of plasma proteins.
Note: In addition to ACD-A, Heparin is also an appropriate anti-coagulant when processing the CenTrate device. See instructions for concentration guidelines.
Features of the CenTrate Device include:
Dual buoy design eliminates need to filter bone marrow prior to processing
5-19x increase in MSCs compared to original bone marrow
Natural fibrin matrix
Bone marrow is often aspirated to utilize the stem cells for tissue repair applications.
Bone marrow aspirate (BMA) is a rich source of MSCs and other osteoprogenitor cells in the body.
The Role of Bone Marrow: The role of bone marrow in the body is to create blood and the
vascular system. When bone marrow cells concentrate at an injury site they initiate new blood vessel formation to start the next phase of the healing process.
Bone Marrow Aspirate Concentrate
The CenTrate Bone Marrow Aspirate Concentration device efficiently concentrates cells and platelets in a natural suspension of plasma proteins in 15 minutes. The dual buoy design eliminates the need to filter bone marrow prior to processing.
Contains Cells and Cytokines
Mesenchymal stem cells (MSCs),2 endothelial progenitor cells (EPCs),3 and hematopoietic stem cells (HSCs).4
High concentrations of interleukin-1 receptor antagonist (IL-1ra or IRAP)5 and tissue healing growth factors.6
Figure 1: Schematic representation of a bone marrow aspiration to acquire cells from blood and bone marrow. Blood contains platelets, white blood cells, and red blood cells. Bone marrow contains white blood cells and musculoskeletal progenitor cells.
The bone marrow aspirate (BMA) needle (sold separately) used with the CenTrate Device
Six holes at the distal tip for better aspiration
3cc or 6cc of cell-rich solution
Available in 30 ml and 60 ml
Each needle comes with a trocar point and blunt tip
What's needed to process and administer the CenTrate 60ml Device...
Owl Manor Centrifuge
Green (60 ml) Centrifuge Buckets
Blue (60 ml) Counterbalance - Adjustable or Solid
The items below are not included:
For bone marrow harvest (Heparin or ACD-A):
Anti-coagulant - Heparin or ACD-A
(1 or 2) 60-ml syringe (Luer-lock recommended) to harvest marrow
For Step 1 (following 1st spin)
(1) 30-ml syringe to draw / remove Platelet Poor Plasma
(1) 10-ml (Luer-lock recommended) syringe to draw out BMA concentrate